How long to cook meatloaf at 375 | Maria Mentiras

By Maria Gutierrez

Cooking a delicious, juicy meatloaf can seem complicated. Whether you’re new to the kitchen or an experienced chef looking for meal ideas, knowing how long to cook your meal is essential. In this blog post, we’ll give you all the information needed on how long to cook meatloaf at 375. From what type of pan to use and how thick your slices should be, we’ve got it all covered. Keep reading to find out just what knowledge and tips are needed in order to make that mouth-watering masterpiece come to life!

What Is Meatloaf?

Meatloaf is a traditional dish consisting of ground meat, seasonings, and other ingredients such as bread crumbs or vegetables. It’s typically shaped into a loaf and then baked in the oven. Meatloaf can also be cooked on top of the stove or in a slow cooker for moist, convenient meals.

What Is Meatloaf?
What Is Meatloaf?

Why Cook Meatloaf at 375°F?

Cooking your meatloaf at 375°F ensures that it stays moist and juicy while cooking. The high temperature helps to seal in the flavors of the beef, spices, and other ingredients. Additionally, cooking at a slightly lower temperature (350°F) for pre-seasoned loaves prevents the seasoning from burning and ensures that all the flavors are evenly distributed throughout the dish.

It’s also important to note that cooking your meatloaf at 375°F helps to reduce shrinkage. As the beef cooks, its proteins begin to contract and expel moisture, resulting in a slightly smaller loaf than when it went into the oven. Cooking at a higher temperature can help minimize this shrinkage.

How Long To Cook Meatloaf At 375°F?

Let’s answer the big question: How long to cook meatloaf at 375?

For best results, you should cook your meatloaf at 375°F for 30-45 minutes for a one-pound loaf and 45-60 minutes for a larger two-pound loaf. If you’re using a pre-seasoned meatloaf, reduce the temperature to 350°F and adjust the cooking time accordingly. You can also check the internal temperature of your meatloaf with a food thermometer to make sure it’s cooked all the way through before serving. With these tips in mind, you’ll be able to cook the perfect meatloaf every time. Bon appetit!

What Affects The Time And Temperature To Cook A Meatloaf?

The time and temperature needed to cook a meatloaf depend on several factors. These include the size of the loaf, its shape, any added ingredients, and even whether it has been pre-seasoned or not. In general, larger loaves will require longer cooking times than smaller ones. For example, a two-pound loaf should be cooked for around 45 minutes, while a smaller one-pound loaf may only need 30 minutes.

How To Cook Meatloaf At 375°F?

Besides understanding the question of how long to cook meatloaf at 375, knowing how To Cook Meatloaf At 375°F? is also important.

The Classic Meatloaf Recipe


  • 2 lbs. ground beef
  • 1 cup breadcrumbs
  • 1/2 cup milk
  • 2 eggs, beaten
  • 1/2 cup chopped onion
  • 1/2 cup chopped green bell pepper
  • 1/2 cup ketchup
  • 2 tbsp. Worcestershire sauce
  • 1 tsp. salt
  • 1/2 tsp. black pepper

Preparing the Meatloaf

Unleash your inner chef and embark on a culinary adventure as you combine 2 pounds of delectable ground beef with a cup of crispy breadcrumbs, a velvety 1/2 cup of milk, and 2 eggs whisked to perfection. With an adventurous spirit, delve into the mixture using your hands or a trusty spoon, blending the ingredients until harmoniously unified.

Elevate the flavors by introducing 1/2 cup each of finely chopped onion and vibrant green bell pepper, followed by the irresistible duo of 1/2 cup ketchup and 2 tablespoons of Worcestershire sauce. Enhance the creation with a touch of 1 teaspoon salt and a dash of 1/2 teaspoon black pepper to suit your taste buds.

Mingle the ingredients with fervor, ensuring an even and delicious unity.

Lovingly transfer your masterpiece to a 9×5 inch loaf pan, smoothing the surface with a nimble spoon or spatula to achieve the perfect shape.

For the bold and daring, consider adorning your meatloaf with tantalizing toppings or seasonings, such as a delectable layer of bacon or a whimsical sprinkle of herbs, before it embarks on its baking journey.

How To Cook Meatloaf At 375°F?
How To Cook Meatloaf At 375°F?

Cooking the Meatloaf

Discover the art of crafting the ideal meatloaf – baked to perfection at a temperature of 375°F (190°C). This precise temperature ensures that the scrumptious masterpiece is evenly cooked, succulent, and bursting with flavors, while displaying a delightful golden-brown appearance.

  1. Ready to introduce your beautifully crafted meatloaf to its warm haven? Gently slide it into the welcoming embrace of your preheated oven, set to a cozy 375°F (190°C).
  2. Savor the excitement as your meatloaf transforms over the course of 60-75 captivating minutes, culminating in that magical 160°F (70°C) milestone. A meat thermometer’s grand entrance into the heart of your mouthwatering creation holds the key to unlocking the perfect balance of tenderness and taste.
  3. Once a tantalizing 45 minutes have passed, feel free to grace your sizzling meatloaf with an extra glaze of ketchup or BBQ sauce to elevate its flavors to divine heights.
  4. Allow your tantalizing meatloaf to repose in its cozy loaf pan for a brief 10-minute interlude after its oven adventure, prior to delving into its succulent depths for an exquisite dining experience.
  5. For those seeking culinary flair, consider indulging in a captivating crispy meatloaf crust. Achieve it effortlessly by allowing the dish to bask under the broiler for a tantalizing 2-3 minutes before presenting it to your guests.

Alternative Cooking Temperatures 

How long to cook meatloaf at 375 and Can you to modify your cooking temperature? Remember, this impacts the overall cooking time. Discover these general principles for alternative heat levels:

  • Cooking at 350°F (175°C) will require an additional 10-15 minutes of cook time.
  • Cooking at 400°F (205°C) will require a shorter cook time of 45-60 minutes.
  • Cooking at 425°F (218°C) will require an even shorter cook time of 35-45 minutes.

Remember, cooking durations can fluctuate based on your meatloaf’s unique size and form. To guarantee a perfect 160°F (70°C) safe temperature, be sure to use a trusty meat thermometer to check its core.

Testing for Doneness and Letting it Rest of meatloaf

When it comes to meatloaf, the most important thing to remember is that you need to make sure it’s cooked through before serving. To check for doneness, insert a thermometer into the center of the loaf and make sure it reads 160°F (70°C). Once your meatloaf reaches this temperature, remove it from the oven and let it rest for 10 minutes before slicing. This will allow the juices to redistribute throughout the loaf, creating a juicy, flavorful meal that your family is sure to love.

Tips for Perfectly Cooked Meatloaf

Tips on how to achieve a moist and flavorful meatloaf

– Use a combination of ground beef and pork, or other types of meat, for added flavor.

– Soak the breadcrumbs in milk before adding them to the mixture to make a juicier meatloaf.

– Add vegetables such as onions, garlic, celery, carrots, or peppers for additional flavor and nutrition.

– Use ketchup, BBQ sauce, or other types of tomato sauces as your glaze on top of the meatloaf.

– Add herbs and spices to give the meatloaf more flavor.

– Let the cooked meatloaf rest for 10 minutes before slicing it so that it holds together better and stays juicy.

– Always check the internal temperature of the meatloaf with a thermometer to ensure it has reached 160°F (70°C).

By following these tips, you can be sure that your meatloaf will come out perfectly cooked and moist every time. Enjoy!

Tips for Perfectly Cooked Meatloaf
Tips for Perfectly Cooked Meatloaf

Suggestions for seasoning and sauce options

– Basil, oregano, thyme, garlic powder, onion powder, paprika, and cayenne pepper are great herbs and spices to use in the meatloaf mixture.

– For a sweet glaze or topping on your meatloaf you can use ketchup, BBQ sauce, honey mustard, teriyaki sauce, hoisin sauce, or even a combination of some of these.

– For a savory topping you can use cheese, bacon bits, Parmesan cheese, diced ham or sausage links.

– You can also add vegetables such as bell peppers, mushrooms, onions and garlic for extra flavor and nutrition. 

– If you want some extra crunch, top the meatloaf with French fried onions or buttered panko breadcrumbs.

By experimenting with different seasonings and sauces, you can find a combination that suits your taste and creates a delicious meal. Enjoy!

Conclusion How Long To Cook Meatloaf At 375°F?

It is important to remember that the best way to know when your meatloaf is cooked through and ready to serve is by using a thermometer. Cook times may vary based on the size and shape of the loaf, so use a thermometer to ensure it has reached a safe temperature of 160°F (70°C). To achieve a moist and flavorful meatloaf, use a combination of meats, vegetables, seasonings and sauces. Finally, let the cooked meatloaf rest for 10 minutes before slicing to allow the juices to redistribute throughout the loaf. Thank you for reading How long to cook meatloaf at 375? with Maria Mentiras Bar And Grill

FAQs about cooking meatloaf

What is the ideal temperature to cook meatloaf?

The ideal temperature to cook meatloaf is 350°F. This will allow the meat to cook evenly without becoming too dry.

What are the risks of cooking meatloaf at 375°F?

Experience the perfect harmony of tenderness and scrumptiousness in your meatloaf by avoiding a 375°F oven setting. This temperature often results in an undesirable overcooked exterior and potentially undercooked interior, robbing your dish of its delectable taste and pleasing texture.

What are the consequences of cooking meatloaf at too high or too low of a temperature?

To achieve a perfectly moist and tender meatloaf, it’s crucial to strike the right balance in cooking temperature. Overly high heat can lead to an undesirable mix of an overcooked crust with an undercooked core, while very low temperatures may inadvertently invite uneven cooking and potential bacterial growth.

How do I know when my meatloaf is cooked through at 375°F?

Use a meat thermometer to ensure it’s cooked through! Aim for an internal temp of 160°F for beef and pork, and 165°F for chicken and turkey – your dinner guests will thank you!

What are some signs that my meatloaf is overcooked or undercooked?

An overcooked meatloaf will be dry and tough, while an undercooked meatloaf will be pink and moist.

Can I cook meatloaf at 375°F in a convection oven?

Absolutely! Meatloaf can be perfectly cooked in a convection oven at 375°F. Remember to tweak the cooking time as convection ovens tend to be speedier than their traditional counterparts.

Can I cook meatloaf at 375°F in a toaster oven?

Yes, you can create a delectable meatloaf in a toaster oven, set at 375°F. Just ensure that the meatloaf’s dimensions don’t exceed the oven’s capacity, for a perfectly cooked dish.

Can I cook meatloaf at 375°F in a slow cooker?

Avoid preparing meatloaf at 375°F using a slow cooker, as these appliances usually fail to achieve the necessary heat to ensure a safe serving temperature.

Can I cook meatloaf at 375°F in an Instant Pot?

Yes, you can cook meatloaf at 375°F in an Instant Pot. However, you will need to use a trivet or other elevated surface to keep the meatloaf from sitting in its own juices.

Can I cook meatloaf at 375°F on the grill?

Certainly! An Instant Pot can deliver savory meatloaf at 375°F with ease. Elevate the dish using a trivet or a similar tool, ensuring that the luscious loaf doesn’t rest in its flavorful juices, and you’ll have mouths watering in anticipation.

Can I cook meatloaf at 375°F in the microwave?

Experience the full potential of your meatloaf dish by avoiding the use of a microwave at 375°F. This cooking method may lead to uneven results, compromising the perfection of your culinary masterpiece.

Can I cook meatloaf at 375°F in an air fryer?

It is not recommended to cook meatloaf at 375°F in an air fryer, as the meatloaf may not cook evenly and may become dry.

What are some common mistakes people make when cooking meatloaf at 375°F?

Don’t let these rookie errors sabotage your culinary masterpiece! Ensure a perfect dish by avoiding overmixing, using ample binding agents, opting for juicy meat, and vigilantly monitoring the internal temperature with a trusty meat thermometer.

What are some helpful hints for cooking meatloaf at 375°F?

Unleash your inner chef by mastering the art of meatloaf at 375°F! Keep a trusty meat thermometer by your side to achieve that perfect 160°F core, practice patience while your creation takes a breather before carving, and shower your mixture with moisture to experience unrivaled succulence.

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